Postodoctoral position to study dopamine signaling in regulation of insulin and glucagon secretion
An NIH R01-funded postdoctoral position is available immediately to study dopamine signaling in modulating pancreatic hormone secretion and its roles in antipsychotic drug-induced diabetes. The Freyberg laboratory studies the roles of dopamine signaling in central nervous system and the periphery in metabolism. We recently showed that dopamine plays a key role in modulating hormone release from pancreatic alpha- and beta-cells. We also find that dopamine receptors in alpha-cells and beta-cells are the primary molecular targets of antipsychotic drugs, some of the most prescribed psychiatric medications today. Importantly, these medications often produce insulin resistance and ultimately can lead to type 2 diabetes. Until recently, there was no clear mechanism for antipsychotic dru
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