A postdoctoral Research Fellow position is available immediately in Dr. Mattia Quattrocelli's laboratory in the Division of Molecular Cardiovascular Biology in the Heart Institute. The Quattrocelli lab investigates the interplay between metabolic, circadian and epigenetic mechanisms to govern pharmacology and physiology of cardiovascular disease and skeletal muscle disorders. We are expanding our research interest from basic mechanisms of striated muscle function to complex disease contexts like aging, diabetes, heart failure and muscle wasting. Moreover, we are interested in linking functional outcomes to the crosstalk between striated muscle cells and other cells or tissues of relevance, such as adipose tissue, liver, immune cells, etc. The studies in our lab routinely use multidisciplinary combinations of transgenic mice, omics datasets, metabolic assays, circadian modulation, in vitro/ex vivo isotope tracing, primary cell lines and human induced pluripotent stem cells. The laboratory is committed to support postdoctoral fellows in any career aspirations (academia, industry, etc.).
Recent publications from the lab: 1) Wintzinger et al, Impact of circadian time of dosing on cardiomyocyte-autonomous effects of glucocorticoids, Mol Metab. 2022. 2) Quattrocelli et al, Intermittent prednisone treatment in mice promotes exercise tolerance in obesity through adiponectin. J Exp Med. 2022. 3) Quattrocelli et al, Muscle mitochondrial remodeling by intermittent glucocorticoid drugs requires an intact circadian clock and muscle PGC1??. Sci Adv. 2022.
MAJOR DUTIES AND RESPONSIBILITIES: ??? Design, execute, and record laboratory experiments, and analyze the data. ??? Research and improve current methods and evaluate innovative techniques. Implement this knowledge in the Division/Department. ??? Present research at laboratory meetings, journal clubs, seminars, and meetings. ??? Draft, write, and edit scientific reports, papers, journal articles, abstracts, and grants. ??? Maintain currency in field through continuing education, literature, and seminars. ??? Attend required Cincinnati Children's training sessions and ensure regulatory compliance with all policies and procedures. ??? Perform other duties as assigned.
Cincinnati Children's Research and Training at a Glance
Among the top in NIH funding for pediatric research institutions
Over 1.4 million square feet of research laboratory space
900+ scientists conducting basic, translational, and clinical research
Over 2000 publications annually in top-tier journals
Access to Employee Resource Groups and Mentorship programs
Postdocs have gone on to careers in academia, biotech, pharma, teaching etc.
REQUIRED ??? Ph.D. in related discipline, MD, or equivalent required.
Recent Ph.D. candidates with research experience in molecular/cellular biology, biochemistry and/or physiology are encouraged to apply. Previous experience with mouse physiology and/or primary/pluripotent cell culture is preferred but not required. The ideal candidate should work well in teams as well as independently, and be organized, self-motivated and hardworking.
REQUIRED SKILLS: Excellent written, verbal, and interpersonal communication skills. Demonstrate attention to detail, strong organizational skills, supervisory ability, and an innovative approach to experimental design. Computer literate and working knowledge of software applications (word processing, spreadsheet, and database). Analytical ability sufficient to compare data; mathematical ability sufficient to perform algebraic calculations and statistical analysis. Ability to synthesize information and to create and deal with new situations by applying past experiences. Expressed willingness to teach others and share results. Capable of meeting time demands necessary to execute experiments.
At Cincinnati Children’s, we come to work with one goal: to make children’s health better. We believe in a team approach, both in caring for patients and their families, and in advancing science and discovery. We strive to do better, and find energy and inspiration in our shared purpose. If you want to be the best you can be, you can do it at Cincinnati Children’s.